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赵宇亮、谷战军课题组在Advanced Materials发表论文
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| 2017-11-25 | 浏览次数: | 文章来源: | 【大 中 小】 |
Synthesis of BSA-Coated BiOI@Bi2S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor
作者：Zhao Guo, Shuang Zhu, Yuan Yong, Xiao Zhang, Xinghua Dong, Jiangfeng Du, Jiani Xie, Qing Wang, Zhanjun Gu,* and Yuliang Zhao*
Advanced materials 卷:29期:44 DOI:10.1002/adma.201704136
出版年:2017-Nov (Epub 2017 Oct 16)
摘要：Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. Here, BiOI@Bi2 S3 @BSA (bovine serum albumin) semiconductor heterojunction nanoparticles (SHNPs) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (CT/PA) bioimaging are reported. On the one hand, SHNPs possess strong X-ray attenuation capability since they contain high-Z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement. On the other hand, as a semiconductor, the as-prepared SHNPs offer an extra approach for reactive oxygen species generation based on electron-hole pair under the irradiation of X-ray through the photodynamic therapy process. This X-ray excited photodynamic therapy obviously has better penetration depth in bio-tissue. What's more, the SHNPs also possess well photothermal conversion efficiency for photothermal therapy, because Bi2 S3 is a thin band semiconductor with strong near-infrared absorption that can cause local overheat. In vivo tumor ablation studies show that synergistic radio/photodynamic/photothermal therapy achieves more significant therapeutic effect than any single treatment. In addition, with the strong X-ray attenuation and high near-infrared absorption, the as-obtained SHNPs can also be applied as a multimodal contrast agent in CT/PA imaging.
发表原文链接：
http://onlinelibrary.wiley.com/doi/10.1002/adma.201704136/abstract;jsessionid=AB304B518EAF959D377976F0C7D3C0B9.f03t01
媒体报道：BiOI@Bi2S3半导体异质结纳米诊疗剂用于协同增强肿瘤放射治 |
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