Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues 
作者：Jiangfeng Du, Zhanjun Gu,* Liang Yan, Yuan Yong, Xuan Yi, Xiao Zhang, Jing Liu, Renfei Wu, Cuicui Ge, Chunying Chen,* and Yuliang Zhao* 

Advanced Materials  卷: 29期: 34文献号: 1701268   
DOI: 10.1002/adma.201701268   
出版年: SEP 13 2017   

摘要：The development of a new generation of nanoscaled radiosensitizers that can not only enhance radiosensitization of tumor tissues, but also increase radioresistance of healthy tissue is highly desirable, but remains a great challenge. Here, this paper reports a new versatile theranostics based on poly(vinylpyrollidone)- and selenocysteine-modified Bi2Se3 nanoparicles (PVP-Bi2Se3@Sec NPs) for simultaneously enhancing radiotherapeutic effects and reducing the side-effects of radiation. The as-prepared nanoparticles exhibit significantly enhanced free-radical generation upon X-ray radiation, and remarkable photothermal effects under 808 nm NIR laser irradiation because of their strong X-ray attenuation ability and high NIR absorption capability. Moreover, these PVP-Bi2Se3@Sec NPs are biodegradable. In vivo, part of selenium can be released from NPs and enter the blood circulation system, which can enhance the immune function and reduce the side-effects of radiation in the whole body. As a consequence, improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo. Moreover, there is no significant in vitro and in vivo toxicity of PVP-Bi2Se3@Sec NPs during the treatment, which demonstrates that PVP-Bi2Se3@Sec NPs have good biocompatibility. 

发表原文链接：http://onlinelibrary.wiley.com/doi/10.1002/adma.201701268/full
学术媒体报道：聚（乙烯基吡咯烷酮）和硒代半胱氨酸修饰的Bi2Se3纳米颗粒增强对肿瘤组织放疗效果的同时提升正常组织的放疗防护功能